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The support cells that build a tumour's scaffolding come in several types: some protect the tumour, others restrain it. Treating all of them the same way explains past failures.
Attempts to strip tumour stroma wholesale, including hyaluronidase in pancreatic cancer and hedgehog inhibition, failed or worsened outcomes, consistent with the finding that some fibroblast subsets restrain tumour growth. Human single-cell and spatial atlases now define myofibroblastic, inflammatory and antigen-presenting fibroblast states. A classifier that assigns patients to stroma-directed treatment by subtype, rather than by disease, is the logical next step.
Shares Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs, Desmoplasia (tumour stroma), Single-cell & spatial profiling, Digital pathology & AI.
Shares Erik Sahai, Desmoplasia (tumour stroma), Failures are hidden, Pancreatic ductal adenocarcinoma.
Shares Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs, Single-cell & spatial profiling, Cold tumours and the immunosuppressive microenvironment, Pancreatic ductal adenocarcinoma.
Shares Desmoplasia (tumour stroma), FAP, Single-cell & spatial profiling, Pancreatic ductal adenocarcinoma.
Shares Consensus molecular subtypes (CMS1-4), Desmoplasia (tumour stroma), RNA sequencing & expression profiling, Colorectal cancer.
Shares Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs, Cold tumours and the immunosuppressive microenvironment, RNA sequencing & expression profiling, Biomarkers are not validated or standardised.
Shares Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs, FAP, Single-cell & spatial profiling, Cold tumours and the immunosuppressive microenvironment.
Shares FAP, Single-cell & spatial profiling, Cold tumours and the immunosuppressive microenvironment.