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When attacked, cells switch on a survival programme that buys them time to adapt. Blocking that programme could turn a partial response into a complete one.
The integrated stress response, heat shock factor 1 activity and autophagy are rapidly induced after targeted therapy and support survival during the adaptation window. Inhibitors of eIF2B-mediated stress signalling, HSF1 and autophagy exist at various stages of development. The proposal is combination timed to the adaptation window (the first days after therapy initiation) rather than continuous co-dosing.
Shares Drug resistance (primary and acquired), Acquired resistance to every therapy, Minimal / molecular residual disease (MRD).
Shares Drug resistance (primary and acquired), Acquired resistance to every therapy, Minimal / molecular residual disease (MRD).
Shares Drug resistance (primary and acquired), Acquired resistance to every therapy.
Shares Drug resistance (primary and acquired), Acquired resistance to every therapy.
Shares Drug resistance (primary and acquired), Acquired resistance to every therapy.
Shares Drug resistance (primary and acquired), Acquired resistance to every therapy.
Shares Drug resistance (primary and acquired), Acquired resistance to every therapy.
Shares Drug resistance (primary and acquired), Acquired resistance to every therapy.