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Deliver genetic instructions so the cancer cell itself manufactures a molecule that traps its driver protein inside the cell.
Intrabodies (single-domain antibodies or designed binders expressed intracellularly) can sequester or degrade targets that small molecules cannot reach. mRNA-LNP delivery makes transient intracellular expression feasible without viral vectors, and fusion to a degron converts binding into destruction. Delivery specificity and expression level are the open questions rather than the biology.
Shares Orna Therapeutics (Eli Lilly), Moderna, Drugging the 'undruggable' cancer targets, Personalised neoantigen (mRNA) vaccines.
Shares Orna Therapeutics (Eli Lilly), Moderna, Personalised neoantigen (mRNA) vaccines.
Shares Drugging the 'undruggable' cancer targets, The undruggable drivers, PROTACs & molecular glues (targeted protein degradation).
Shares Drugging the 'undruggable' cancer targets, The undruggable drivers, PROTACs & molecular glues (targeted protein degradation).
Shares Drugging the 'undruggable' cancer targets, The undruggable drivers, PROTACs & molecular glues (targeted protein degradation).
Shares Drugging the 'undruggable' cancer targets, The undruggable drivers.
Shares Drugging the 'undruggable' cancer targets, The undruggable drivers.
Shares Drugging the 'undruggable' cancer targets, The undruggable drivers, PROTACs & molecular glues (targeted protein degradation).