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Blood tests tell you which tumour sub-populations are growing; scans tell you which lesions are growing. Joining the two would tell you where to biopsy or irradiate.
Tissue-of-origin methylation, lesion-specific private mutations from multi-site biopsies, and lesion volume kinetics from serial imaging could be combined in a joint model that assigns plasma clone fractions to anatomical lesions. This would let clinicians direct local therapy at the lesion carrying the expanding resistant clone without biopsying every site.
Shares DNA methylation profiling, Tumour heterogeneity and clonal evolution, Liquid biopsy (ctDNA).
Shares Metastasis is understood least and studied last, Tumour heterogeneity and clonal evolution.
Shares Whole-body MRI, Liquid biopsy (ctDNA).
Shares Tumour heterogeneity and clonal evolution, Liquid biopsy (ctDNA).
Shares Tumour heterogeneity and clonal evolution, Liquid biopsy (ctDNA).