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A tiny peptide instead of an antibody carries the same payload as Padcev to Nectin-4, with far less rash and neuropathy in early data, but its developer stepped back in 2026.
Duravelo-2 (randomised phase 2/3): encouraging responses and a differentiated safety profile (skin reactions ~4-fold lower, neuropathy half that of enfortumab vedotin), presented ASCO 2026. Bicycle Therapeutics deprioritised the programme in March 2026 after regulators indicated the trial design could not support registration.
Ball-and-stick model from PubChem 2D record (no 3D conformer available). PubChem record
Zelenectide pevedotin is a bicyclic-peptide toxin conjugate (no antibody); only the payload is shown.
Bicyclic peptide binds Nectin-4; cleavable linker releases MMAE; rapid renal clearance limits systemic exposure. Connects to Nectin-4.
1.Bicyclic peptide binds Nectin-4 with high affinity
Programme deprioritised after regulatory feedback on Duravelo-2 design source
| Adverse event | Any grade | Grade 3+ |
|---|---|---|
| Fatigue | 40% | - |
| Skin reactions | 13% | - |
| Peripheral neuropathy | 25% | - |
Roughly one quarter the rate reported for enfortumab vedotin. Events listed without rates were not read from a primary source; see the label. Blank cells mean the figure was not sourced, not that it is zero.
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Query for this drug: (TITLE:"Zelenectide pevedotin" OR ABSTRACT:"Zelenectide pevedotin" OR TITLE:"BT8009" OR ABSTRACT:"BT8009") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Zelenectide pevedotin, not a curated reading list.
Shares Nectin-4, Bladder & urothelial cancer.
Shares Nectin-4, Bladder & urothelial cancer.
Shares Nectin-4, Bladder & urothelial cancer.
Shares Nectin-4, Bladder & urothelial cancer.
Shares Nectin-4, Bladder & urothelial cancer.
Shares Nectin-4, Bladder & urothelial cancer.
Shares Nectin-4, Bladder & urothelial cancer.
Shares Nectin-4, Bladder & urothelial cancer.