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Utidelone is Biostar Pharmaceuticals' epothilone chemotherapy, approved in China in 2021 with capecitabine for advanced breast cancer after anthracyclines and taxanes.
Utidelone is a genetically engineered epothilone analogue produced by fermentation, developed by Biostar Pharmaceuticals in Chengdu. The NMPA approved it in March 2021 in combination with capecitabine for recurrent or metastatic breast cancer previously treated with an anthracycline and a taxane, after a phase 3 trial showed longer progression-free and overall survival than capecitabine alone. An oral form is in later trials.
Binds tubulin and locks microtubules in place so that dividing cells cannot complete mitosis; it works in cells that have become resistant to taxanes. Connects to Tubulin (microtubules).
1.Utidelone slips into a pocket on Tubulin (microtubules).
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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| Region | Year | Indication |
|---|---|---|
| CN | 2021 | Recurrent or metastatic breast cancer after anthracycline and taxane, with capecitabine |
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Query for this drug: (TITLE:"Utidelone" OR ABSTRACT:"Utidelone" OR TITLE:"UTD1" OR ABSTRACT:"UTD1" OR TITLE:"Youheng" OR ABSTRACT:"Youheng") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Utidelone, not a curated reading list.
Shares the tags china, nmpa-approved.
Shares the tags china, nmpa-approved.
Shares the tags china, nmpa-approved.
Shares the tags china, nmpa-approved.
Shares the tags china, nmpa-approved.
Shares the tags china, nmpa-approved.
Shares the tags china, nmpa-approved.
Shares the tags china, nmpa-approved.