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Romiplostim is a weekly injection that tells the bone marrow to make more platelets; it is approved for immune thrombocytopenia and for radiation injury, and is being tested for the low platelets that chemotherapy causes.
Romiplostim is an engineered peptibody that mimics thrombopoietin. The United States approved it in 2008 for adults with immune thrombocytopenia (ITP) who had not responded to steroids, immunoglobulins or splenectomy, later extended to children and, separately, to increase survival after acute exposure to myelosuppressive doses of radiation (haematopoietic syndrome of acute radiation syndrome). It is not approved for chemotherapy-induced thrombocytopenia, the commonest reason platelets fall in cancer care, but randomised trials in that setting are under way and haematologists use it off label when platelet counts would otherwise delay treatment.
A peptide fused to an antibody Fc fragment that binds and activates the thrombopoietin receptor MPL, increasing platelet production by megakaryocytes. Connects to MPL (thrombopoietin receptor).
1.Romiplostim slips into a pocket on MPL (thrombopoietin receptor).
| Region | Year | Indication |
|---|---|---|
| US | 2008 | Immune thrombocytopenia with insufficient response to corticosteroids, immunoglobulins or splenectomy · Later extended to children and to the haematopoietic syndrome of acute radiation syndrome |
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Query for this drug: (TITLE:"Romiplostim" OR ABSTRACT:"Romiplostim" OR TITLE:"Nplate" OR ABSTRACT:"Nplate" OR TITLE:"AMG 531" OR ABSTRACT:"AMG 531") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Romiplostim, not a curated reading list.
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Shares Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia.
Shares Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia.