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Eltrombopag is a daily tablet that raises platelet counts by stimulating the bone marrow; it is approved for immune thrombocytopenia and severe aplastic anaemia, and haematologists also use it when low platelets complicate blood cancers and their treatment.
Eltrombopag is an oral thrombopoietin receptor agonist first approved in the United States in 2008 for chronic immune thrombocytopenia (ITP) that has not responded to steroids, immunoglobulins or splenectomy. Its label also covers thrombocytopenia in hepatitis C to allow interferon treatment and severe aplastic anaemia, a bone marrow failure that sits alongside myelodysplastic syndromes in haematology clinics. It is not approved for chemotherapy-induced thrombocytopenia or for low platelets in leukaemia or myelodysplasia, though it has been studied in both and is used off label. Liver toxicity and a possible increase in marrow fibrosis or blast counts are the main cautions.
A small molecule that binds the transmembrane part of the thrombopoietin receptor (MPL) on megakaryocytes and their precursors, driving them to make platelets. Connects to MPL (thrombopoietin receptor).
1.Eltrombopag slips into a pocket on MPL (thrombopoietin receptor).
| Region | Year | Indication |
|---|---|---|
| US | 2008 | Chronic immune thrombocytopenia with insufficient response to corticosteroids, immunoglobulins or splenectomy · Later extended to thrombocytopenia in chronic hepatitis C and to severe aplastic anaemia |
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Query for this drug: (TITLE:"Eltrombopag" OR ABSTRACT:"Eltrombopag" OR TITLE:"Promacta" OR ABSTRACT:"Promacta" OR TITLE:"Revolade" OR ABSTRACT:"Revolade" OR TITLE:"Eltrombopag Olamine" OR ABSTRACT:"Eltrombopag Olamine" OR TITLE:"SB-497115" OR ABSTRACT:"SB-497115") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Eltrombopag, not a curated reading list.
Shares Thrombocytopenia and the tag supportive-care.
Shares Myelodysplastic syndromes / neoplasms (MDS) and the tag supportive-care.
Shares Oprelvekin, Thrombocytopenia.
Shares Study Impact on Outcome of Eltrombopag in Elderly Patients with Acute Myeloid Leukemia Receiving Induction Chemotherapy, Acute myeloid leukaemia.
Shares Myelodysplastic syndromes / neoplasms (MDS), Novartis.
Shares Myelodysplastic syndromes / neoplasms (MDS), Novartis.
Shares Thrombocytopenia, Myelodysplastic syndromes / neoplasms (MDS).
Shares Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia.