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IDRX-42 is an experimental small-molecule drug from GlaxoSmithKline in phase 3 trials for gastrointestinal stromal tumour, with its target not yet stated publicly.
IDRX-42 is a small-molecule drug developed by GlaxoSmithKline. Its molecular target is not stated in the ClinicalTrials.gov intervention record, and OnCo has not confirmed one from the sponsor's pipeline page. It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial, including the phase 3 study NCT07218926 (A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumours After Imatinib Therapy), in gastrointestinal stromal tumour. The largest, NCT07218926, plans to enrol 450 participants with primary completion expected 2028-05-30. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.
Mechanism not stated in the ClinicalTrials.gov record or on the sponsor's pipeline page.
1.IDRX-42 slips into a pocket on its target.
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Query for this drug: (TITLE:"IDRX-42" OR ABSTRACT:"IDRX-42" OR TITLE:"velzatinib - subject to USAN approval" OR ABSTRACT:"velzatinib - subject to USAN approval") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IDRX-42, not a curated reading list.
Shares KIT exon 11-mutant GIST, Imatinib-resistant GIST, Gastrointestinal stromal tumour (GIST) and the tag pipeline.
Shares Imatinib-resistant GIST, Gastrointestinal stromal tumour (GIST) and the tag pipeline.
Shares KIT exon 11-mutant GIST, Imatinib-resistant GIST, Gastrointestinal stromal tumour (GIST) and the tag pipeline.
Shares Gastrointestinal stromal tumour (GIST), GSK and the tag pipeline.
Shares GSK and the tag pipeline.
Shares GSK and the tag pipeline.
Shares GSK and the tag pipeline.
Shares GSK and the tag pipeline.