A sea-sponge-derived chemotherapy that extended survival in heavily pretreated breast cancer and in liposarcoma, where almost nothing else had.
EMBRACE (Lancet 2011): OS 13.1 vs 10.6 months versus treatment of physician's choice in pretreated metastatic breast cancer. Liposarcoma approval 2016 (OS 15.6 vs 8.4 months versus dacarbazine in the liposarcoma subgroup). Neuropathy and neutropenia; the payload of the ADC MORAb-202 (farletuzumab ecteribulin).
Ball-and-stick model from PubChem 2D record (no 3D conformer available). PubChem record
Binds the plus ends of microtubules, suppressing growth without affecting shortening; also reverses EMT and remodels tumour vasculature.
1.Eribulin slips into a pocket on its target.
Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies. Generic eribulin has been approved.
Covered under the medical benefit with prior authorisation confirming diagnosis, biomarker status and line of therapy; site-of-care policies may steer infusions away from hospital outpatient departments. Plans typically require two prior chemotherapy regimens for metastatic breast cancer, per the label.
20% Part B coinsurance on a high-cost infusion adds up quickly: Medigap Plan G or N, Medicare Advantage maximum out-of-pocket, Medicaid dual eligibility, or a charity fund are the usual buffers.
Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B). Not medical or financial advice; verify with your plan.
Sources: NICE TA423 · SMC advice: eribulin. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
| Region | Year | Indication |
|---|---|---|
| US | 2010 | Metastatic breast cancer after ≥2 regimens including an anthracycline and a taxane |
| US | 2016 | Unresectable or metastatic liposarcoma after anthracycline |
| EU | 2011 | Metastatic breast cancer; liposarcoma (2016) |
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Eribulin is an approved later-line treatment for liposarcoma, one of the few sarcoma drugs with a demonstrated survival benefit.
One treatment page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
Query for this drug: (TITLE:"Eribulin" OR ABSTRACT:"Eribulin" OR TITLE:"Halaven" OR ABSTRACT:"Halaven") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Eribulin, not a curated reading list.
Shares A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Unresectable Locally Advanced, Recurrent, or Metastatic HR+HER2- Breast Cancer(PANKU-Breast01), Study of SKB264 for Locally Advanced, Recurrent or Metastatic HR+/HER2- Breast Cancer, A Study of TQB2930 for Injection Monotherapy or Combination Therapy in Patients With Recurrent/Metastatic Breast Cancer, SYD985 vs. Physician's Choice in Participants With HER2-positive Locally Advanced or Metastatic Breast Cancer.
Shares Retroperitoneal sarcoma, Liposarcoma, Soft tissue sarcoma of the extremity (localised and advanced), Uterine sarcoma.
Shares EMBRACA, OlympiAD, ASCENT, Triple-negative breast cancer (TNBC).
Shares EMBRACA, OlympiAD, Metastatic triple-negative breast cancer, Triple-negative breast cancer (TNBC).
Shares Retroperitoneal sarcoma, Soft tissue sarcoma of the extremity (localised and advanced), Uterine sarcoma, Sarcomas (soft tissue, bone, GIST).
Shares A Study of BL-M07D1 Versus Investigator's Choice of Chemotherapy in Patients With HER2-low Recurrent/Metastatic Breast Cancer, A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Unresectable Locally Advanced, Recurrent, or Metastatic HR+HER2- Breast Cancer(PANKU-Breast01), A Study of SKB264 Versus Investigator's Choice Chemotherapy in Patients With Unresectable Recurrent or Metastatic Triple-Negative Breast Cancer, Study of JSKN016 Combination Therapy in Inoperable Locally Advanced or Metastatic HER2-Negative Breast Cancer.
Shares Eribulin versus dacarbazine in previously treated advanced liposarcoma or leiomyosarcoma, Liposarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Retroperitoneal sarcoma, Soft tissue sarcoma of the extremity (localised and advanced), Uterine sarcoma, Sarcomas (soft tissue, bone, GIST).