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Enrylaze is a replacement asparaginase for children and adults with acute lymphoblastic leukaemia or lymphoblastic lymphoma whose bodies have reacted against, or quietly neutralised, the usual E. coli asparaginase. It keeps the asparagine-starving part of their chemotherapy going.
Crisantaspase (Enrylaze) is authorised in the EU since 15 September 2023 (CHMP opinion 20 July 2023; marketing authorisation holder Jazz Pharmaceuticals Ireland Limited) as a component of a multi-agent chemotherapeutic regimen for acute lymphoblastic leukaemia and lymphoblastic lymphoma in adults and children from one month of age who have developed hypersensitivity or silent inactivation to E. coli-derived asparaginase. It is under additional monitoring in the EU. The class record `asparaginase` covers pegaspargase, calaspargase pegol and the native Erwinia enzyme; this record is the recombinant Erwinia product.
Asparaginase enzyme that depletes circulating asparagine, on which lymphoblasts depend; the recombinant Erwinia enzyme is given to patients who have reacted to or silently inactivated E. coli-derived asparaginase (indication wording, EMA).
1.Crisantaspase (recombinant Erwinia asparaginase) binds its target.
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| Region | Year | Indication |
|---|---|---|
| EU | 2023 | ALL and lymphoblastic lymphoma, in a multi-agent regimen, after hypersensitivity or silent inactivation to E. coli-derived asparaginase (adults and children from 1 month) · Authorised 15 Sep 2023; Jazz Pharmaceuticals Ireland |
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Query for this drug: (TITLE:"Crisantaspase" OR ABSTRACT:"Crisantaspase" OR TITLE:"recombinant Erwinia asparaginase" OR ABSTRACT:"recombinant Erwinia asparaginase" OR TITLE:"Enrylaze" OR ABSTRACT:"Enrylaze" OR TITLE:"crisantaspase" OR ABSTRACT:"crisantaspase" OR TITLE:"recombinant Erwinia chrysanthemi asparaginase" OR ABSTRACT:"recombinant Erwinia chrysanthemi asparaginase" OR TITLE:"JZP-458" OR ABSTRACT:"JZP-458") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Crisantaspase (recombinant Erwinia asparaginase), not a curated reading list.
Shares Eryaspase, Acute lymphoblastic leukaemia.
Shares COG AALL1731, Standard-risk B-cell acute lymphoblastic leukaemia in children, Acute lymphoblastic leukaemia.
Shares Asparaginase (pegaspargase, calaspargase pegol, Erwinia asparaginase), High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL), Acute lymphoblastic leukaemia.
Shares Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome, Standard-risk B-cell acute lymphoblastic leukaemia in children, High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL).
Shares Asparaginase (pegaspargase, calaspargase pegol, Erwinia asparaginase), High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL), Acute lymphoblastic leukaemia.
Shares Standard-risk B-cell acute lymphoblastic leukaemia in children, High-risk acute lymphoblastic leukaemia in children (high-risk B-ALL and T-ALL), Acute lymphoblastic leukaemia.