Cabazitaxel

• Partly comes backNerves in the hands and feet: Numbness and tingling from a taxane usually fade over the months after treatment, but about a third of the people who had moderate or severe symptoms at the end of docetaxel still have them one to three years later. 34% of those with grade 2 to 4 neuropathy at the end of treatment were still affected at 1 to 3 years (1,031 early breast cancer patients treated with docetaxel, Denmark). Long-term neuropathy after adjuvant docetaxel, European Journal of Cancer 2015
• Partly comes backNerves in the hands and feet: Two years after starting a docetaxel-containing regimen, four in ten women still report some nerve symptoms, and more of the drug means more of the symptom. 41.9% reported peripheral neuropathy at 2 years (1,512 women with node-positive early breast cancer in NSABP B-30). Patient-reported peripheral neuropathy in NRG Oncology/NSABP B-30, JNCI 2018
• Partly comes backFertility: Periods stop during chemotherapy for most young women, and most get them back in the second year; taxane-containing regimens left more women without periods at a year than the same chemotherapy without one. amenorrhoea at 1 year 286 of 789 (36.2%) and at 2 years 120 of 699 (17.2%); by regimen at 1 year, 44.1% after doxorubicin, cyclophosphamide and paclitaxel and 41.8% after docetaxel and cyclophosphamide against 25% after doxorubicin and cyclophosphamide alone (the Young Women's Breast Cancer Study, women diagnosed aged 40 or under, enrolled 2006 to 2016, several regimens). Treatment-related amenorrhoea in the Young Women's Breast Cancer Study, npj Breast Cancer 2021
• Partly comes backSkin and nails: Hair grows back after a taxane for most people, but in a substantial minority it comes back thinner and does not fully return, and three years on the picture has not improved. 39.5% at 6 months and 42.3% at 3 years had persistent chemotherapy-induced alopecia (61 women with stage I to III breast cancer, prospective cohort, Samsung Medical Center, Seoul). Permanent chemotherapy-induced alopecia in patients with breast cancer, The Oncologist 2019
• Partly comes backEyes: Watering eyes on docetaxel usually settle, but if the tear ducts scar and the scarring is left alone it can become permanent, so this is worth reporting early. Ophthalmic side effects of targeted and cytotoxic agents, Ophthalmic Plastic and Reconstructive Surgery 2017

Read for the class this product belongs to (taxanes) unless the answer names the product. Population figures from the cohorts named, not a prediction for one person. Blank where no source gives a recovery figure.