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Algenpantucel-L was a whole-cell pancreatic cancer vaccine given after surgery; the phase 3 IMPRESS trial showed no survival benefit.
NewLink Genetics designed algenpantucel-L to exploit hyperacute rejection, the reaction that destroys pig organs in humans. A phase 2 study after pancreatic cancer surgery reported encouraging survival, which led to the largest adjuvant vaccine trial in the disease.
IMPRESS randomised 722 patients with resected pancreatic cancer to standard adjuvant gemcitabine with or without chemoradiation, with or without algenpantucel-L. Overall survival was not improved, and a second phase 3 in borderline resectable and locally advanced disease (PILLAR) was also negative.
Irradiated pancreatic cancer cell lines engineered to express alpha-1,3-galactosyl, a sugar humans lack, so pre-existing anti-alpha-gal antibodies attack the vaccine cells and, in theory, train immunity against shared tumour antigens.
1.Algenpantucel-L slips into a pocket on its target.
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Query for this drug: (TITLE:"Algenpantucel-L" OR ABSTRACT:"Algenpantucel-L" OR TITLE:"HyperAcute Pancreas" OR ABSTRACT:"HyperAcute Pancreas") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Algenpantucel-L, not a curated reading list.
Shares Pancreatic cancer: the failed and stopped programmes and why, Off-the-shelf cancer vaccines, Metastatic pancreatic ductal adenocarcinoma, Pancreatic ductal adenocarcinoma.
Shares Pancreatic cancer: the failed and stopped programmes and why, Metastatic pancreatic ductal adenocarcinoma, Pancreatic ductal adenocarcinoma.
Shares Pancreatic cancer: the failed and stopped programmes and why, Off-the-shelf cancer vaccines, Metastatic pancreatic ductal adenocarcinoma, Pancreatic ductal adenocarcinoma.
Shares Pancreatic cancer: the failed and stopped programmes and why, Metastatic pancreatic ductal adenocarcinoma, Pancreatic ductal adenocarcinoma.
Shares Cancer vaccines and oncolytic viruses, Pancreatic ductal adenocarcinoma.
Shares Pancreatic cancer: the failed and stopped programmes and why, Metastatic pancreatic ductal adenocarcinoma, Pancreatic ductal adenocarcinoma.
Shares Pancreatic cancer: the failed and stopped programmes and why, Metastatic pancreatic ductal adenocarcinoma, Pancreatic ductal adenocarcinoma.
Shares Pancreatic cancer: the failed and stopped programmes and why, Metastatic pancreatic ductal adenocarcinoma, Pancreatic ductal adenocarcinoma.