Charles River Laboratories

Charles River Laboratories, based in Wilmington, Massachusetts, and listed as CRL, is a preclinical contract research organisation for safety and discovery studies that also offers viral vector and cell therapy manufacturing services. Its work spans discovery and safety assessment, including toxicology and patient-derived xenograft models through its oncology services, and CDMO capacity for plasmid, vector and cell therapy production. OnCo links it to viral vector manufacturing, patient-derived xenografts, contract research organisations and cell-therapy release and potency testing. Whether the preclinical models it sells predict what happens in patients is the question that hangs over the whole CRO sector. The CRO technology page carries the wider picture.