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DrugBank & ChEMBL
DrugBank and ChEMBL hold the chemistry and mechanism of every drug and most tool compounds.
Overview
DrugBank and ChEMBL are the two reference databases of drugs and bioactive molecules, with targets, mechanisms and pharmacology, and between them they cover the chemistry and mechanism of every drug and most tool compounds. ChEMBL, run by EMBL-EBI under CC BY-SA, holds more than two million compounds with bioactivities; DrugBank, from the University of Alberta and free for academic use, provides structured drug-target-interaction data. On OnCo the pair is linked to the institution EMBL's European Bioinformatics Institute and cited by the bottlenecks Too many combinations to test and No incentive to repurpose cheap drugs. It also supports ideas such as An open engine that ranks every drug pair by predicted synergy before anyone runs a trial.
Holds
Drug and bioactive molecule databases with targets, mechanisms, and pharmacology.
Licence
ChEMBL CC BY-SA; DrugBank free academic
Maintainer
EMBL-EBI; University of Alberta
Similar pages
- IdeaA standard cross-company combination agreement that takes weeks, not years, to sign
Shares Every approved cancer drug ships with a public combination-readiness data pack, Too many combinations to test.
- IdeaAn open forecasting tournament on which combination trials will succeed
Shares An open engine that ranks every drug pair by predicted synergy before anyone runs a trial, Too many combinations to test.
- CollectionDepMap (Cancer Dependency Map)
Shares A drug screen that only rewards killing sleeping cancer cells, An open engine that ranks every drug pair by predicted synergy before anyone runs a trial, Too many combinations to test.
- IdeaA public atlas of drug-pair responses across a thousand patient-derived organoids
Shares An open engine that ranks every drug pair by predicted synergy before anyone runs a trial, Too many combinations to test.
- IdeaFactorial trials that test several cheap generics at once in the adjuvant setting
Shares No incentive to repurpose cheap drugs, Too many combinations to test.
- IdeaPatient-derived organoids to pick ADC payloads
Shares An open engine that ranks every drug pair by predicted synergy before anyone runs a trial, Too many combinations to test.
- CollectionFDA Oncology Approvals (OCE) & Novel Drug Approvals
Shares Every approved cancer drug ships with a public combination-readiness data pack, Require every oncology candidate to publish how much reaches the brain.
- Key paperCombination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy
Shares Every approved cancer drug ships with a public combination-readiness data pack, Too many combinations to test.
institutions
ideas
A commons of shelved cancer drugs with their full data, open to new hypothesesA drug screen that only rewards killing sleeping cancer cellsA shared compound library that rare cancer researchers can actually useAn open engine that ranks every drug pair by predicted synergy before anyone runs a trialEvery approved cancer drug ships with a public combination-readiness data packPre-registered, publicly scored AI ranking of repurposing candidates for cancerRequire every oncology candidate to publish how much reaches the brain
collections
bottlenecks
Open-source projects
All open source in oncology →Open-source projects that are the code behind this collection or publish it, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
The official Python client for ChEMBL, EMBL-EBI's open database of bioactive molecules and their assay data.