What changed: Uterine sarcoma

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Median PFS 12.

Pautier and colleagues, Lancet Oncol.

NTRK fusion-positive solid tumours, including colorectal cancer

NTRK fusion-positive solid tumours in adults and children, locally advanced or metastatic or where surgery would cause severe morbidity, with no satisfactory treatment options: NICE TA630 (27 May 2020) recommends it within the Cancer Drugs Fund under a managed access agreement

Adjuvant chemotherapy for stage I LMS did not improve outcomes; observation is standard.

Seddon and colleagues, Lancet Oncol; doxorubicin retained as first line.

Unsuspected uterine sarcoma disseminated by morcellation during fibroid surgery.

Lee and colleagues; earlier Koontz 2001 for JAZF1.

A milestone in how this cancer is treated.