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Adding olaparib to bevacizumab maintenance roughly doubled progression-free time in tumours with faulty DNA repair, and improved survival in that group.
PFS 22.1 vs 16.6 months overall (HR 0.59) and 37.2 vs 17.7 months in HRD-positive tumours (HR 0.33; NEJM 2019). Five-year OS in HRD-positive patients was 65.5% vs 48.4% (HR 0.62; Annals of Oncology 2023). No benefit in HRD-negative disease. Approved in 2020 for HRD-positive tumours; it established HRD testing as a decision point.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
806 enrolled.
Shares myChoice CDx, HRD genomic scar scores (GIS, LOH, HRDetect), High-grade serous ovarian cancer, Platinum-sensitive ovarian cancer.
Shares Isabelle Ray-Coquard, High-grade serous ovarian cancer, Platinum-sensitive ovarian cancer, Homologous recombination deficiency (HRD).
Shares High-grade serous ovarian cancer, Platinum-sensitive ovarian cancer, PARP, PARP inhibitors.
Shares Isabelle Ray-Coquard, myChoice CDx, ARCAGY-GINECO, Society of Gynecologic Oncology.
Shares Homologous recombination deficiency (HRD), PARP, PARP inhibitors, Olaparib.
Shares High-grade serous ovarian cancer, Platinum-sensitive ovarian cancer, Homologous recombination deficiency (HRD), PARP.
Shares HRD genomic scar scores (GIS, LOH, HRDetect), High-grade serous ovarian cancer, Homologous recombination deficiency (HRD), PARP.
Shares PARP, PARP inhibitors, Olaparib, BRCA1 / BRCA2 (HRD).