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Trials
A Study of Rocbrutinib in Combination With Lacutoclax in Patients With B-Cell Malignancies

trialsTrialRecruiting

A Study of Rocbrutinib in Combination With Lacutoclax in Patients With B-Cell Malignancies

A phase 1/2 trial of Rocbrutinib in mantle cell lymphoma and diffuse large b-cell lymphoma, run by Guangzhou Lupeng Pharmaceutical Company LTD., now recruiting.

Overview Connected5

Overview

A Study of Rocbrutinib in Combination With Lacutoclax in Patients With B-Cell Malignancies is a phase 1/2 interventional study registered as NCT07609862 by Guangzhou Lupeng Pharmaceutical Company LTD., with 92 participants planned, started 2026-07-14 and due to reach its primary completion in 2029-06-30. Interventions recorded: Lacutoclax+Rocbrutinib. Conditions listed: Mantle Cell Lymphoma (MCL), Diffuse Large B-Cell Lymphoma (DLBCL), Follicular Lymphoma ( FL), Waldenström Macroglobulinemia (WM). No results are recorded here; the registry entry is the source.

Setting

A Phase Ib/II, Open-Label, Multicenter Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of BTK Inhibitor Rocbrutinib in Combination With BCL-2 Inhibitor Lacutoclax in Patients With B-Cell Malignancies

Phase

Phase 1/2

Sponsor

Guangzhou Lupeng Pharmaceutical Company LTD.

Registry

Started

2026-07-14

Enrolled

92 enrolled

Connected

Similar pages

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A Study of Rocbrutinib in Participants With Relapse or Refractory Mantle Cell Lymphoma
Shares Rocbrutinib, Lupeng Pharmaceuticals, Mantle cell lymphoma.
Trial
A Study of Rocbrutinib Versus Investigator's Choice of BTK Inhibitors in Patients With Relapsed or Refractory Mantle Cell Lymphoma
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Trial
A Study of Rocbrutinib in Participants With Relapse or Refractory Non-GCB Diffuse Large B-Cell Lymphoma
Shares Rocbrutinib, Lupeng Pharmaceuticals, Diffuse large B-cell lymphoma.
Treatment
Bendamustine
Shares Lupeng Pharmaceuticals, Mantle cell lymphoma, Follicular lymphoma, Diffuse large B-cell lymphoma.

cancers

Diffuse large B-cell lymphoma Follicular lymphoma Mantle cell lymphoma

drugs

Phase 3small molecule

companies

Lupeng Pharmaceuticals

Evidence strength18/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
92 enrolled+10
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Orphan trials · diff · file

Sources & links

ClinicalTrials.gov NCT07609862

Data

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Cancers

Mantle cell lymphoma
Diffuse large B-cell lymphoma
Follicular lymphoma

Products

Rocbrutinib

Companies

Lupeng Pharmaceuticals

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