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Trials
A Phase II Study of AK146D1 Combined With AK112 in Advanced Breast Cancer

trialsTrialRecruiting

A Phase II Study of AK146D1 Combined With AK112 in Advanced Breast Cancer

A phase 2 trial of AK146D1 in advanced solid tumours, run by Akeso, now recruiting.

Overview Connected4

Overview

A Phase II Study of AK146D1 Combined With AK112 in Advanced Breast Cancer is a phase 2 interventional study registered as NCT07591090 by Akeso, with 200 participants planned, started 2026-07-17 and due to reach its primary completion in 2027-09-01. Interventions recorded: AK146D1 for injection and AK112 Injection.

Setting

A Phase II Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Anti-tumor Efficacy of AK146D1 Combined With AK112 in Patients With Advanced Breast Cancer

Phase

Phase 2

Sponsor

Akeso

Registry

Started

2026-07-17

Enrolled

200 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

drugs

Phase 1Bispecific ADC

companies

Evidence strength27/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
200 enrolled+12
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT07591090

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

Bispecific ADC

Products

AK146D1

Companies

Akeso

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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