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Trials
Phase 1/2 Study of EB-NK-301 (Allogeneic TROP2-CAR NK Cells) in Advanced TROP2-Expressing Solid Tumors

trialsTrialRecruiting

Phase 1/2 Study of EB-NK-301 (Allogeneic TROP2-CAR NK Cells) in Advanced TROP2-Expressing Solid Tumors

A phase 1/2 trial of EB-NK-301 and Fludarabine in advanced solid tumours, run by Beijing Biotech, now recruiting.

Overview Connected4

Overview

Phase 1/2 Study of EB-NK-301 (Allogeneic TROP2-CAR NK Cells) in Advanced TROP2-Expressing Solid Tumors is a phase 1/2 interventional study registered as NCT07589530 by Beijing Biotech, with 60 participants planned, started 2026-03-02 and due to reach its primary completion in 2027-02-14. Interventions recorded: EB-NK-301 and Fludarabine.

Setting

A Phase 1/2, Open-Label, Dose-Escalation and Dose-Expansion Study Evaluating the Safety, Tolerability, and Preliminary Anti-tumor Activity of EB-NK-301 (Allogeneic TROP2-Targeted CAR NK Cells) Following Lymphodepleting Chemotherapy in Adults With Advanced or Metastatic TROP2-Expressing Solid Tumors

Phase

Phase 1/2

Sponsor

Beijing Biotech

Registry

Started

2026-03-02

Enrolled

60 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

CAR-NK & CAR-macrophage

drugs

Phase 2CAR-NK cell therapy

ApprovedPurine nucleotide analogue (antimetabolite)

Fludarabine · Fludara (historic)

Evidence strength22/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
60 enrolled+9
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT07589530

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

CAR-NK & CAR-macrophage

Products

EB-NK-301
Fludarabine

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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