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Trials
Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer

trialsTrialRecruiting

Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer

A phase 2 trial of Nivolumab, Bevacizumab in colorectal cancer, run by Gilead Sciences, now recruiting.

Overview Connected5

Overview

Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer is a phase 2 interventional study registered as NCT07527858 by Gilead Sciences, with 170 participants planned, started 2026-05-19 and due to reach its primary completion in 2028-12. Interventions recorded: Denikitug, Nivolumab, Bevacizumab, Trifluridine-Tipiracil. Conditions listed: Advanced Microsatellite Stable Colorectal Cancer. No results are recorded here; the registry entry is the source.

Setting

A Phase 2, Open Label, Multicenter, Randomized Study, to Evaluate the Efficacy and Safety of Denikitug Monotherapy and Denikitug-based Combinations in Participants With Advanced Microsatellite Stable (MSS) Colorectal Cancer (CRC)

Phase

Phase 2

Sponsor

Gilead Sciences

Registry

Started

2026-05-19

Enrolled

170 enrolled

Connected

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Target
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Shares Gilead Sciences (incl. Kite), Immune checkpoint inhibitors.

cancers

Colorectal cancer

technologies

Immune checkpoint inhibitors

drugs

ApprovedMonoclonal antibody (anti-VEGF)

Bevacizumab · Avastin (and biosimilars)

ApprovedMonoclonal antibody (anti-PD-1)

Nivolumab · Opdivo / Opdivo Qvantig (SC)

companies

Gilead Sciences (incl. Kite)

Evidence strength31/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
170 enrolled+11
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT07527858

Data

JSON ·

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Cancers

Colorectal cancer

Technologies

Immune checkpoint inhibitors

Products

Nivolumab
Bevacizumab

Companies

Gilead Sciences (incl. Kite)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

Machine-readable versions of Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer

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MCP server: npx -y onco-mcp, tools search, get_entity, list_kind, ask, context, compare. This record is get_entity or context with id nct07527858.

WebMCP tools registered on this page: onco_search, onco_get_entity.