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Trials
A Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of LRK-4189 Alone and in Combination in Patients With Solid Tumors

trialsTrialRecruiting

A Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of LRK-4189 Alone and in Combination in Patients With Solid Tumors

A phase 1/2 trial of LRK-4189 escalation in advanced solid tumours, run by LARKSPUR BIOSCIENCES, INC., now recruiting.

Overview Connected5

Overview

A Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of LRK-4189 Alone and in Combination in Patients With Solid Tumors is a phase 1/2 interventional study registered as NCT07498725 by LARKSPUR BIOSCIENCES, INC., with 120 participants planned, started 2026-07-07 and due to reach its primary completion in 2029-06. Interventions recorded: LRK-4189 escalation, LRK-4189 expansion, LRK-4189 optimization and Chemo.

Setting

A Phase 1b-2, Open-Label, Dose-Escalation, Expansion and Optimization Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of LRK-4189 Alone and in Combination With mFOLFOX6 or FOLFIRI in Patients With Solid Tumors

Phase

Phase 1/2

Sponsor

LARKSPUR BIOSCIENCES, INC.

Registry

Started

2026-07-07

Enrolled

120 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

Cytotoxic chemotherapy Platinum agents

drugs

ApprovedCytotoxic regimen

FOLFIRI (5-FU, leucovorin, irinotecan)

ApprovedCytotoxic regimen

FOLFOX (5-FU, leucovorin, oxaliplatin)

Evidence strength23/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
120 enrolled+10
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT07498725

Data

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

Cytotoxic chemotherapy
Platinum agents

Products

FOLFOX (5-FU, leucovorin, oxaliplatin)
FOLFIRI (5-FU, leucovorin, irinotecan)

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