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Trials
Study of AZD4956 as Monotherapy and in Combination With Anti-Cancer Agents in Participants With Advanced/Metastatic Homologous Recombination Deficient Solid Tumours

trialsTrialRecruiting

Study of AZD4956 as Monotherapy and in Combination With Anti-Cancer Agents in Participants With Advanced/Metastatic Homologous Recombination Deficient Solid Tumours

A phase 1/2 trial of Saruparib in advanced solid tumours, run by AstraZeneca, now recruiting.

Also called: PARTHENON

Overview Connected3

Overview

Study of AZD4956 as Monotherapy and in Combination With Anti-Cancer Agents in Participants With Advanced/Metastatic Homologous Recombination Deficient Solid Tumours is a phase 1/2 interventional study registered as NCT07446855 by AstraZeneca, with 180 participants planned, started 2026-03-17 and due to reach its primary completion in 2030-03-29. Interventions recorded: AZD4956 and Saruparib.

Setting

A Modular Open-label, Phase I/IIa Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of Ascending Doses of AZD4956 as Monotherapy, and in Combination With Anti-Cancer Agents in Participants With Advanced/Metastatic Homologous Recombination Repair Defective Solid Tumours

Phase

Phase 1/2

Sponsor

AstraZeneca

Registry

Started

2026-03-17

Enrolled

180 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

drugs

Phase 3small molecule

companies

Evidence strength19/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
180 enrolled+11
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Add 115 registry trial acronyms from the CT.gov acronym f… · diff · file

Sources & links

ClinicalTrials.gov NCT07446855

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Products

Saruparib

Companies

AstraZeneca

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Model panel commentary is coming to this page: machine commentary, not clinical review.

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