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Trials
A Phase Ⅰ/Ⅱa Study of HMPL-A251 in Participants With Advanced or Metastatic HER2-expressing Solid Tumors

trialsTrialRecruiting

A Phase Ⅰ/Ⅱa Study of HMPL-A251 in Participants With Advanced or Metastatic HER2-expressing Solid Tumors

A phase 1/2 trial of HMPL-A251 in advanced solid tumours, run by Hutchmed, now recruiting.

Overview Connected2

Overview

A Phase Ⅰ/Ⅱa Study of HMPL-A251 in Participants With Advanced or Metastatic HER2-expressing Solid Tumors is a phase 1/2 interventional study registered as NCT07228247 by Hutchmed, with 147 participants planned, started 2025-12-16 and due to reach its primary completion in 2028-11-30. Interventions recorded: HMPL-A251.

Setting

A Phase Ⅰ/Ⅱa Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity and Preliminary Efficacy of HMPL-A251 in Participants With Advanced or Metastatic HER2-Expressing Solid Tumors

Phase

Phase 1/2

Sponsor

Hutchmed

Registry

Started

2025-12-16

Enrolled

147 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

companies

Evidence strength19/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
147 enrolled+11
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-16 · Jude Gomila · Registry trials wave 6 and products wave 7 · diff · file

Sources & links

ClinicalTrials.gov NCT07228247

Data

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