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Trials
Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

trialsTrialRecruiting

Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

A phase 1/2 trial of Palacaparib in prostate cancer, run by AstraZeneca, now recruiting.

Also called: SEACLIFF

Overview Connected3

Overview

Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer is a phase 1/2 interventional study registered as NCT07181161 by AstraZeneca, with 283 participants planned, started 2025-10-01 and due to reach its primary completion in 2029-01-18. Interventions recorded: AZD0516, AZD9574. Conditions listed: Metastatic Prostate Cancer. No results are recorded here; the registry entry is the source.

Setting

A Modular Phase I/IIa, Open-label, Multi-centre Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of AZD0516 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Metastatic Prostate Cancer

Phase

Phase 1/2

Sponsor

AstraZeneca

Registry

Started

2025-10-01

Enrolled

283 enrolled

Connected

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cancers

Prostate cancer

drugs

Phase 2small molecule

companies

Evidence strength20/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
283 enrolled+12
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Add 115 registry trial acronyms from the CT.gov acronym f… · diff · file

Sources & links

ClinicalTrials.gov NCT07181161

Data

JSON ·

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Cancers

Prostate cancer

Products

Palacaparib

Companies

AstraZeneca

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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