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Trials
A Study of Safety, Tolerability and Preliminary Efficacy of NTS071 in Subjects With Advanced Solid Tumors Harboring a TP53 Y220C Mutation

trialsTrialRecruiting

A Study of Safety, Tolerability and Preliminary Efficacy of NTS071 in Subjects With Advanced Solid Tumors Harboring a TP53 Y220C Mutation

A phase 1/2 trial of NTS071 in advanced solid tumours, run by Nutshell Therapeutics (Shanghai) Co., LTD., now recruiting.

Overview Connected2

Overview

A Study of Safety, Tolerability and Preliminary Efficacy of NTS071 in Subjects With Advanced Solid Tumors Harboring a TP53 Y220C Mutation is a phase 1/2 interventional study registered as NCT07060989 by Nutshell Therapeutics (Shanghai) Co., LTD., with 220 participants planned, started 2025-08-04 and due to reach its primary completion in 2028-12. Interventions recorded: NTS071.

Setting

A Phase 1/2a Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of NTS071 in Subjects With Advanced Solid Tumors Harboring a TP53 Y220C Mutation

Phase

Phase 1/2

Sponsor

Nutshell Therapeutics (Shanghai) Co., LTD.

Registry

Started

2025-08-04

Enrolled

220 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

targets

Evidence strength20/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
220 enrolled+12
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Backlink fill · diff · file

Sources & links

ClinicalTrials.gov NCT07060989

Data

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