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Trials
A First-in-human Study of PARP1 Selective Inhibitor, IMP1734, in Participants With Advanced Solid Tumors

trialsTrialRecruiting

A First-in-human Study of PARP1 Selective Inhibitor, IMP1734, in Participants With Advanced Solid Tumors

A phase 1/2 trial of IMP1734 in advanced solid tumours, run by Eikon Therapeutics, now recruiting.

Overview Connected4

Overview

A First-in-human Study of PARP1 Selective Inhibitor, IMP1734, in Participants With Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT06253130 by Eikon Therapeutics, with 156 participants planned, started 2023-12-11 and due to reach its primary completion in 2027-06-01. Interventions recorded: IMP1734.

Setting

A First-in-human, Phase 1/2, Open-label, Multi-center, Dose-escalation, Dose-optimization, and Dose-expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Anti-tumor Activity of PARP1 Selective Inhibitor, IMP1734, as Monotherapy in Patients With Advanced Solid Tumors

Phase

Phase 1/2

Sponsor

Eikon Therapeutics

Registry

Started

2023-12-11

Enrolled

156 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

drugs

Phase 2Small-molecule inhibitor

companies

Eikon Therapeutics IMPACT Therapeutics

Evidence strength19/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
156 enrolled+11
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-17 · Jude Gomila · Reverse links for orphaned drugs and companies · diff · file

Sources & links

ClinicalTrials.gov NCT06253130

Data

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Cancers

Metastatic cancer (cancer that has spread)

Products

IMP1734

Companies

Eikon Therapeutics
IMPACT Therapeutics

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

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