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Trials
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

trialsTrialRecruiting

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

A phase 3 trial of Cyclophosphamide and Retifanlimab in advanced solid tumours, run by BriaCell Therapeutics Corporation, now recruiting.

Also called: BRIA-ABC

Overview Connected3

Overview

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer. is a phase 3 interventional study registered as NCT06072612 by BriaCell Therapeutics Corporation, with 404 participants planned, started 2023-12-05 and due to reach its primary completion in 2027-12. Interventions recorded: SV-BR-1-GM, Cyclophosphamide, Interferon infiltration of the inoculation site, Retifanlimab and Treatment of Physician's Choice.

Setting

Randomized, Open-Label Study of the Bria-IMT Regimen and Check Point Inhibitor vs Physicians' Choice in Advanced Metastatic Breast Cancer.

Phase

Phase 3

Sponsor

BriaCell Therapeutics Corporation

Registry

Started

2023-12-05

Enrolled

404 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

drugs

ApprovedAlkylating agent (oxazaphosphorine prodrug)

Cyclophosphamide · Cytoxan / Endoxan

ApprovedAnti-PD-1 monoclonal antibody (IgG4)

Retifanlimab · Zynyz

Evidence strength48/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 3+30
404 enrolled+13
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Trial acronyms for registry records · diff · file

Sources & links

ClinicalTrials.gov NCT06072612

Data

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Cancers

Metastatic cancer (cancer that has spread)

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Cyclophosphamide
Retifanlimab

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