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Trials
Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors

trialsTrialRecruiting

Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors

A phase 1/2 trial of Antibody-Drug Conjugate in advanced solid tumours, run by MBrace Therapeutics, now recruiting.

Overview Connected2

Overview

Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors is a phase 1/2 interventional study registered as NCT06014658 by MBrace Therapeutics, with 130 participants planned, started 2023-11-07 and due to reach its primary completion in 2026-07. Interventions recorded: Antibody-Drug Conjugate.

Setting

A Multicenter, Open-label, Phase 1/1b / Phase 2 Dose Finding, Safety, and Pharmacokinetic Study of MBRC-101, an Anti-EphA5 Monomethyl Auristatin E (MMAE) Antibody Drug Conjugate, in Advanced Refractory Solid Tumors

Phase

Phase 1/2

Sponsor

MBrace Therapeutics

Registry

Started

2023-11-07

Enrolled

130 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

companies

MBrace Therapeutics

Evidence strength19/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
130 enrolled+11
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-16 · Jude Gomila · Registry trials wave 6 and products wave 7 · diff · file

Sources & links

ClinicalTrials.gov NCT06014658

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Companies

MBrace Therapeutics

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