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Trials
IMA402 T Cell-Engaging Receptor Molecule (TCER®) in Recurrent and/or Refractory Solid Tumors

trialsTrialRecruiting

IMA402 T Cell-Engaging Receptor Molecule (TCER®) in Recurrent and/or Refractory Solid Tumors

A phase 1/2 trial of IMA402 in advanced solid tumours, run by Immatics Biotechnologies GmbH, now recruiting.

Overview Connected3

Overview

IMA402 T Cell-Engaging Receptor Molecule (TCER®) in Recurrent and/or Refractory Solid Tumors is a phase 1/2 interventional study registered as NCT05958121 by Immatics Biotechnologies GmbH, with 400 participants planned, started 2023-08-09 and due to reach its primary completion in 2027-09. Interventions recorded: IMA402, IMA402 and checkpoint inhibitor, IMA402 and chemotherapy, IMA402 and IMA401, IMA402 and monoclonal antibody and IMA402 and chemotherapy +/- monoclonal antibody.

Setting

A Phase I/II First-In-Human Clinical Trial to Evaluate the Safety, Tolerability and Anti-Tumor Activity of IMA402, a Bispecific T Cell-Engaging Receptor Molecule (TCER®) Targeting PRAME, as Monotherapy or in Combination With a Checkpoint Inhibitor in Patients With Recurrent and/or Refractory Solid Tumors

Phase

Phase 1/2

Sponsor

Immatics Biotechnologies GmbH

Registry

Started

2023-08-09

Enrolled

400 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

targets

companies

Evidence strength21/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
400 enrolled+13
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Backlink fill · diff · file

Sources & links

ClinicalTrials.gov NCT05958121

Data

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Cancers

Metastatic cancer (cancer that has spread)

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PRAME

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Immatics

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MCP server: npx -y onco-mcp, tools search, get_entity, list_kind, ask, context, compare. This record is get_entity or context with id nct05958121.

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