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Trials
Study of ART6043 in Advanced/Metastatic Solid Tumors Patients (POLKA)

trialsTrialRecruiting

Study of ART6043 in Advanced/Metastatic Solid Tumors Patients (POLKA)

A phase 1/2 trial of Olaparib in advanced solid tumours, run by Artios Pharma Ltd, now recruiting.

Also called: POLKA

Overview Connected4

Overview

Study of ART6043 in Advanced/Metastatic Solid Tumors Patients (POLKA) is a phase 1/2 interventional study registered as NCT05898399 by Artios Pharma Ltd, with 181 participants planned, started 2023-06-30 and due to reach its primary completion in 2028-06-30. Interventions recorded: ART6043 and Olaparib.

Setting

A Phase I/IIa, Open-label, Multi-center Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of the DNA Polymerase Theta Inhibitor ART6043 Administered Orally as Monotherapy and in Combination to Patients With Advanced or Metastatic Solid Tumors

Phase

Phase 1/2

Sponsor

Artios Pharma Ltd

Registry

Started

2023-06-30

Enrolled

181 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

PARP inhibitors

drugs

ApprovedSmall-molecule PARP inhibitor

Olaparib · Lynparza

companies

Evidence strength24/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
181 enrolled+11
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 5 sponsor companies · diff · file

Sources & links

ClinicalTrials.gov NCT05898399

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

PARP inhibitors

Products

Olaparib

Companies

Artios Pharma

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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