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Trials
Combination of GNS561 and Trametinib in Patients With Advanced KRAS Mutated Cholangiocarcinoma

trialsTrialRecruiting

Combination of GNS561 and Trametinib in Patients With Advanced KRAS Mutated Cholangiocarcinoma

A phase 1/2 trial of Trametinib in biliary tract cancer, run by Genfit, now recruiting.

Overview Connected3

Overview

Combination of GNS561 and Trametinib in Patients With Advanced KRAS Mutated Cholangiocarcinoma is a phase 1/2 interventional study registered as NCT05874414 by Genfit, with 98 participants planned, started 2023-08-21 and due to reach its primary completion in 2027-12. Interventions recorded: GNS561 + Trametinib.

Setting

Phase 1b/2a Study of GNS561 in Combination With Trametinib in Advanced KRAS Mutated Cholangiocarcinoma

Phase

Phase 1/2

Sponsor

Genfit

Registry

Started

2023-08-21

Enrolled

98 enrolled

Connected

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cancers

Biliary tract cancer (cholangiocarcinoma)

technologies

Small-molecule kinase inhibitors

drugs

ApprovedSmall-molecule allosteric MEK1/2 inhibitor

Trametinib · Mekinist

Evidence strength23/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
98 enrolled+10
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT05874414

Data

JSON ·

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Cancers

Biliary tract cancer (cholangiocarcinoma)

Technologies

Small-molecule kinase inhibitors

Products

Trametinib

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