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Trials
A Study of HST-1011 Given as Monotherapy and in Combination With an Anti-PD1 Antibody

trialsTrialActive

A Study of HST-1011 Given as Monotherapy and in Combination With an Anti-PD1 Antibody

A phase 1/2 trial of Cemiplimab in advanced solid tumours, run by HotSpot Therapeutics, Inc, active and no longer recruiting.

Overview Connected4

Overview

A Study of HST-1011 Given as Monotherapy and in Combination With an Anti-PD1 Antibody is a phase 1/2 interventional study registered as NCT05662397 by HotSpot Therapeutics, Inc, with 77 participants enrolled, started 2023-03-15 and due to reach its primary completion in 2025-12-31. Interventions recorded: HST-1011 and Cemiplimab.

Setting

An Open Label, Phase 1/2 Study of HST-1011 Given as Monotherapy and in Combination With an Anti-PD1 Antibody in Patients With Advanced Solid Tumors

Phase

Phase 1/2

Sponsor

HotSpot Therapeutics, Inc

Registry

Started

2023-03-15

Enrolled

77 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

drugs

ApprovedMonoclonal antibody (anti-PD-1)

Cemiplimab · Libtayo

Phase 2Small-molecule inhibitor

companies

HotSpot Therapeutics

Evidence strength22/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
77 enrolled+9
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-17 · Jude Gomila · Reverse links for orphaned drugs and companies · diff · file

Sources & links

ClinicalTrials.gov NCT05662397

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Products

Cemiplimab
HST-1011

Companies

HotSpot Therapeutics

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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