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Trials
A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

trialsTrialRecruiting

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

A phase 2 trial of Plixorafenib in advanced solid tumours, run by Fore Biotherapeutics, now recruiting.

Overview Connected2

Overview

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations is a phase 2 interventional study registered as NCT05503797 by Fore Biotherapeutics, with 254 participants planned, started 2023-02-21 and due to reach its primary completion in 2027-12-31. Interventions recorded: Plixorafenib.

Setting

A Phase 2 Master Protocol to Assess the Efficacy and Safety of FORE8394, an Inhibitor of BRAF Class 1 and Class 2 Alterations, in Participants With Cancer Harboring BRAF Alterations

Phase

Phase 2

Sponsor

Fore Biotherapeutics

Registry

Started

2023-02-21

Enrolled

254 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

targets

Evidence strength27/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
254 enrolled+12
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Backlink fill · diff · file

Sources & links

ClinicalTrials.gov NCT05503797

Data

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Cancers

Metastatic cancer (cancer that has spread)

Targets

BRAF

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