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Trials
A Study of Belzutifan (MK-6482) in Combination With Palbociclib Versus Belzutifan Monotherapy in Participants With Advanced Renal Cell Carcinoma (MK-6

trialsTrialActive

A Study of Belzutifan (MK-6482) in Combination With Palbociclib Versus Belzutifan Monotherapy in Participants With Advanced Renal Cell Carcinoma (MK-6

A phase 1/2 trial of Belzutifan, Palbociclib in renal cell carcinoma, run by Merck Sharp & Dohme LLC, active and no longer recruiting.

Overview Connected6

Overview

A Study of Belzutifan (MK-6482) in Combination With Palbociclib Versus Belzutifan Monotherapy in Participants With Advanced Renal Cell Carcinoma (MK-6482-024/LITESPARK-024) is a phase 1/2 interventional study registered as NCT05468697 by Merck Sharp & Dohme LLC, with 60 participants planned, started 2022-08-10 and due to reach its primary completion in 2026-10-22. Interventions recorded: Belzutifan, Palbociclib. Conditions listed: Renal Cell Carcinoma. No results are recorded here; the registry entry is the source.

Setting

A Multicenter, Open-label, Randomized, Phase 1/2 Study of Belzutifan in Combination With Palbociclib Versus Belzutifan Monotherapy in Participants With Advanced Renal Cell Carcinoma

Phase

Phase 1/2

Sponsor

Merck Sharp & Dohme LLC

Registry

Started

2022-08-10

Enrolled

60 enrolled

Connected

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Trial
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cancers

Renal cell carcinoma

technologies

CDK4/6 inhibitors Small-molecule kinase inhibitors

drugs

ApprovedSmall-molecule HIF-2α inhibitor

Belzutifan · Welireg

ApprovedSmall-molecule CDK4/6 inhibitor

Palbociclib · Ibrance

companies

Merck & Co. (MSD)

Evidence strength22/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
60 enrolled+9
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT05468697

Data

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Cancers

Renal cell carcinoma

Technologies

CDK4/6 inhibitors
Small-molecule kinase inhibitors

Products

Belzutifan
Palbociclib

Companies

Merck & Co. (MSD)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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