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A phase 2 trial of Acalabrutinib and Umbralisib in Chronic lymphocytic leukaemia, run by Jennifer R. Brown, MD, PhD, active and no longer recruiting.
Acalabrutinib, Umbralisib, and Ublituximab (AU2) In Relapsed and Untreated CLL is a phase 2 interventional study registered as NCT04624633 by Jennifer R. Brown, MD, PhD, with 29 participants planned, started 2020-12-15 and due to reach its primary completion in 2023-12-21. Interventions recorded: Acalabrutinib, Umbralisib, Ublituximab. Conditions recorded: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Relapsed Chronic Lymphocytic Leukemia, Refractory Chronic Lymphocytic Leukemia.
Linked to the drug Umbralisib because the registry names it among its interventions and Chronic lymphocytic leukaemia among its conditions. Registry record only: no result has been read by an editor.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
29 enrolled.
95% CI 0.043 to 0.777; Figures from the ClinicalTrials.gov results section (first posted 2025-02-27), not from a publication · 95% CI 0.084 to 0.582
Source| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Complete Remission (CR) Rate After 24 Cyclesprimary | Cohort 1 - Relapsed Disease | 6 | 0.33 proportion of participants | - | - | link |
| Cohort 2 - Treatment Naive | 14 | 0.29 proportion of participants |
Shares Umbralisib, Chronic lymphocytic leukaemia and the tag pipeline.
Shares Acalabrutinib, Chronic lymphocytic leukaemia and the tag pipeline.
Shares Acalabrutinib, Chronic lymphocytic leukaemia and the tag pipeline.
Shares Umbralisib and the tag pipeline.
Shares Acalabrutinib, Chronic lymphocytic leukaemia and the tag pipeline.
Shares Acalabrutinib, Chronic lymphocytic leukaemia and the tag pipeline.
Shares Acalabrutinib, Chronic lymphocytic leukaemia and the tag pipeline.
Shares Acalabrutinib, Chronic lymphocytic leukaemia and the tag pipeline.