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A phase 1/2 trial of Durvalumab, Capivasertib, Oleclumab, Trastuzumab deruxtecan and Datopotamab deruxtecan in triple-negative breast cancer, run by AstraZeneca, active and no longer recruiting.
A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer is a phase 1/2 interventional study registered as NCT03742102 by AstraZeneca, with 243 participants enrolled, started 2018-12-21 and due to reach its primary completion in 2024-11-29. Interventions recorded: Durvalumab, Capivasertib, Oleclumab, Paclitaxel, Trastuzumab deruxtecan and Datopotamab deruxtecan. Results have been posted on the registry.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
243 enrolled.
Figures from the ClinicalTrials.gov results section (first posted 2026-02-02), not from a publication
Source95% CI 13.0 to NA; Figures from the ClinicalTrials.gov results section (first posted 2026-02-02), not from a publication · 95% CI 12.9 to 40.0 · 95% CI 18.6 to 31.9 · 95% CI 18.8 to NA · NA - Not calculable due to insufficient number of events for upper limit of confidence interval · NA - Not calculable due to insufficient number of events for upper limit of confidence interval
Source95% CI 5.4 to 11.3; Figures from the ClinicalTrials.gov results section (first posted 2026-02-02), not from a publication · 95% CI 5.4 to 10.3 · 95% CI 4.8 to 9.3 · 95% CI 8.4 to 16.3 · 95% CI 11.0 to 21.1 · 95% CI 6.9 to 13.8
Source| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Dose Limiting Toxicity (DLT) Eventsprimary | Arm 2 | 6 | 0 participants | - | - | link |
| Arm 5 | 6 | 0 participants | ||||
| Arm 6 | 6 | 0 participants | ||||
| Arm 7 | 6 | 0 participants | ||||
| Overall Survival (Duration) | Arm 1 | 23 | 30 months | - | - | link |
| Arm 2 | 31 | 32.6 months | ||||
| Arm 5 | 33 | 24.8 months | ||||
| Arm 6 | 58 | 30.3 months | ||||
| Arm 7 | 62 | NA - Not calculable due to insufficient number of events for upper limit of confidence interval | ||||
| Arm 8 | 33 | NA - Not calculable due to insufficient number of events for upper limit of confidence interval | ||||
| Progression-free Survival (PFS) | Arm 1 | 23 | 7.3 months | - | - | link |
| Arm 2 | 31 | 6.4 months | ||||
| Arm 5 | 33 | 8.3 months | ||||
| Arm 6 | 58 | 12.6 months | ||||
| Arm 7 | 62 | 14 months | ||||
| Arm 8 | 33 | 11.2 months |
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