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A phase 3 trial of Margetuximab and Trastuzumab in Breast cancer, run by MacroGenics, completed.
Margetuximab Plus Chemotherapy vs Trastuzumab Plus Chemotherapy in the Treatment of HER2+ Metastatic Breast Cancer is a phase 3 interventional study registered as NCT02492711 by MacroGenics, with 624 participants recorded, started 2015-08-24 and reaching its primary completion in 2021-08-11. Interventions recorded: Margetuximab, Trastuzumab, Physician's choice of chemotherapy.. Conditions recorded: HER-2 Positive Breast Cancer, Metastatic Neoplasm.
Linked to the drug Margetuximab because the registry names it among its interventions and Breast cancer among its conditions. Registry record only: no result has been read by an editor.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
624 enrolled.
95% CI 5.52 to 6.97; Figures from the ClinicalTrials.gov results section (first posted 2022-11-23), not from a publication · 95% CI 4.17 to 5.59
Source95% CI 0.66 to 61.44; Figures from the ClinicalTrials.gov results section (first posted 2022-11-23), not from a publication · 95% CI 0.07 to 64.53
Source| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Progression-free Survival (PFS) as Determined by Independent Radiological Review.primary | Margetuximab Plus Chemotherapy | 266 | 5.8 months | 0.76 (0.593 to 0.979) | 0.0334 | link |
| Trastuzumab Plus Chemotherapy | 270 | 4.9 months | ||||
| Overall Survival (OS) Defined as the Number of Days From Randomization to the Date of Death (From Any Cause).primary | Margetuximab Plus Chemotherapy | 266 | 21.6 months | 0.95 (0.774 to 1.165) | 0.6204 | link |
| Trastuzumab Plus Chemotherapy | 270 | 21.9 months |
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Shares Trastuzumab, Breast cancer (all types) and the tag pipeline.
Shares Trastuzumab, Breast cancer (all types) and the tag pipeline.
Shares Trastuzumab, Breast cancer (all types) and the tag pipeline.
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Shares Trastuzumab, Breast cancer (all types) and the tag pipeline.
Shares Trastuzumab, Breast cancer (all types) and the tag pipeline.