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A phase 2 trial of Pixantrone in Breast cancer, run by Alliance for Clinical Trials in Oncology, completed.
Pixantrone Dimaleate in Treating Patients With HER2-Negative Metastatic Breast Cancer is a phase 2 interventional study registered as NCT01086605 by Alliance for Clinical Trials in Oncology, with 46 participants recorded, started 2010-05 and reaching its primary completion in 2012-01. Interventions recorded: pixantrone dimaleate. Conditions recorded: Breast Cancer.
Linked to the drug Pixantrone because the registry names it among its interventions and Breast cancer among its conditions. Registry record only: no result has been read by an editor.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
46 enrolled.
95% CI 0.01 to 0.27; Figures from the ClinicalTrials.gov results section (first posted 2017-02-23), not from a publication · 95% CI 0 to 0.24
Source95% CI 9 to NA; Figures from the ClinicalTrials.gov results section (first posted 2017-02-23), not from a publication · 95% CI 4.7 to NA
Source95% CI 0.224 to 0.629; Figures from the ClinicalTrials.gov results section (first posted 2017-02-23), not from a publication · 95% CI 0.227 to 0.553
Source| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Proportion of Confirmed Tumor Responses (Complete or Partial Response)primary | Arm I/Group A (Pixantrone IV Day 1) | 24 | 0.08 proportion | - | - | link |
| Arm II/Group B (Pixantrone IV Days 1, 8, and 15) | 22 | 0.05 proportion | ||||
| Overall Survival Time | Arm I/Group A (Pixantrone IV Day 1) | 24 | 16.8 months | - | - | link |
| Arm II/Group B (Pixantrone IV Days 1, 8, and 15) | 22 | 9.6 months | ||||
| 6-month Progression-free Survival Rate | Arm I/Group A (Pixantrone IV Day 1) | 24 | 0.375 proportion | - | - | link |
| Arm II/Group B (Pixantrone IV Days 1, 8, and 15) | 22 | 0.265 proportion |
Shares Alliance for Clinical Trials in Oncology, Breast cancer (all types) and the tag pipeline.
Shares Alliance for Clinical Trials in Oncology, Breast cancer (all types) and the tag pipeline.
Shares Pixantrone and the tag pipeline.
Shares Alliance for Clinical Trials in Oncology and the tag pipeline.
Shares Breast cancer (all types) and the tag pipeline.
Shares Breast cancer (all types) and the tag pipeline.
Shares Breast cancer (all types) and the tag pipeline.
Shares Breast cancer (all types) and the tag pipeline.