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KLASS-01 showed that removing an early stomach cancer through keyhole surgery is as safe for long-term survival as open surgery and causes fewer wound complications, which made laparoscopic gastrectomy the standard for early gastric cancer in Korea and beyond.
KLASS-01 was a multicentre non-inferiority trial run by the Korean Laparoendoscopic Gastrointestinal Surgery Study group in patients with clinical stage I gastric adenocarcinoma. Patients were randomised to laparoscopy-assisted or open distal gastrectomy with standard lymph node dissection.
The short-term report found fewer wound complications and similar mortality with the laparoscopic approach. The primary analysis, published in JAMA Oncology in 2019, showed that five-year overall survival after laparoscopic surgery was non-inferior to open surgery. With the Japanese JCOG0912 trial it settled the question for early distal gastric cancer; the follow-on KLASS-02 addressed locally advanced disease.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
1,400 enrolled.
Difference 0.9 percentage points; non-inferiority margin -5 points
SourceTogether with KLASS-01, this trial makes laparoscopic distal gastrectomy the standard for early gastric cancer needing surgery.
Laparoscopic distal gastrectomy is the standard operation for stage I gastric cancer outside endoscopic criteria in East Asia and increasingly elsewhere.
Shares Gastric & gastro-oesophageal junction cancer and the tag subtype-trials.
Shares Gastric & gastro-oesophageal junction cancer and the tag subtype-trials.
Shares Gastric & gastro-oesophageal junction cancer and the tag subtype-trials.
Shares Gastric & gastro-oesophageal junction cancer and the tag subtype-trials.
Shares Gastric & gastro-oesophageal junction cancer and the tag subtype-trials.
Shares Gastric & gastro-oesophageal junction cancer and the tag subtype-trials.
Shares Gastric & gastro-oesophageal junction cancer and the tag subtype-trials.
Shares JCOG0912: laparoscopy-assisted versus open distal gastrectomy for clinical stage IA or IB gastric cancer, Early gastric cancer, Gastric & gastro-oesophageal junction cancer.