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A protein that speeds up a specific chemical reaction by binding its substrate in an active-site pocket. Kinases, PARP and topoisomerases are enzymes and drug targets, because a small molecule lodged in the active site stops the reaction.
Enzymes bind their substrate in a pocket called the active site, convert it, and release the product thousands of times per second. Kinases, which attach phosphate groups, and PARP, which helps repair DNA, are enzymes; so are topoisomerases, which untangle DNA and are the targets of several chemotherapy drugs and ADC payloads. Small-molecule inhibitors usually work by lodging in the active site so the natural substrate cannot enter.
In plain words · PARP is a DNA repair enzyme. Cancers that have already lost one repair system (BRCA) die when this second one is blocked; healthy cells survive.
Showing the target this term concerns: PARP.
Shares Phosphorylation, Kinase.
Shares Phosphorylation, Kinase.
Shares PARP, Pancreatic ductal adenocarcinoma.
Shares PARP, Pancreatic ductal adenocarcinoma.
Shares PARP, Pancreatic ductal adenocarcinoma.
Shares PARP, Pancreatic ductal adenocarcinoma.