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Having outside radiologists who do not know the treatment assignment re-read every scan in a trial.
Blinded independent central review (BICR) means having outside radiologists who do not know the treatment assignment re-read every scan in a trial. Regulators expect it for PFS and ORR endpoints in open-label trials to remove investigator bias, and it is delivered by imaging core labs. Discordance between local and central reads is common and changes event counts, which is why the practice matters for how trial results are interpreted. The term is linked to the Imaging core labs and central review technology and to the endpoint terms RECIST, Progression-free survival (PFS) and Objective response rate (ORR), and it is referenced by the terms Blinded trial and Blinding (double-blind, open-label, placebo-controlled) as one of the ways bias is controlled when full blinding is not possible.
Showing the technology this term belongs to: Imaging core labs and central review.
Shares RECIST, Objective response rate (ORR), Progression-free survival (PFS).
Shares RECIST, Objective response rate (ORR).
Shares RECIST, Progression-free survival (PFS).
Shares RECIST, Progression-free survival (PFS).
Shares Objective response rate (ORR), Progression-free survival (PFS).
Shares RECIST, Progression-free survival (PFS).
Shares RECIST, Progression-free survival (PFS).
Shares RECIST, Progression-free survival (PFS).