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Pills that stop the body making oestrogen (after the menopause, when it comes from fat and muscle rather than the ovaries), starving hormone receptor-positive breast cancer. Taken for five to ten years after surgery, they halve recurrence.
Letrozole, anastrozole and exemestane block the aromatase enzyme; in premenopausal women they only work with ovarian function suppression (GnRH agonist or oophorectomy, SOFT/TEXT). They modestly beat tamoxifen in postmenopausal adjuvant therapy (ATAC, BIG 1-98) and are the partner drug for CDK4/6 inhibitors in metastatic disease. Side effects are joint pain, bone loss (needing bisphosphonates), vaginal dryness and cardiovascular effects, and adherence over 5-10 years is a real problem. Resistance often comes through ESR1 mutations, which favour switching to a SERD.
Showing the molecule this term concerns: Letrozole (and other aromatase inhibitors).
Shares Vaginal oestrogen after breast cancer: what the evidence says, and where it disagrees, Menopause brought on by cancer treatment, and the options for it, Bone loss caused by cancer treatment, and what rebuilds it, Letrozole (and other aromatase inhibitors).
Shares Acupuncture for hot flushes on endocrine therapy, Vaginal oestrogen after breast cancer: what the evidence says, and where it disagrees, Menopause brought on by cancer treatment, and the options for it.
Shares Minoxidil for persistent chemotherapy- and endocrine-therapy hair loss, Letrozole (and other aromatase inhibitors), Tamoxifen, Endocrine therapy (SERMs, AIs, SERDs).
Shares Acupuncture for aromatase-inhibitor joint pain, Acupuncture for hot flushes on endocrine therapy, Vaginal oestrogen after breast cancer: what the evidence says, and where it disagrees, Menopause brought on by cancer treatment, and the options for it.
Shares Selective oestrogen receptor degrader (SERD), Hormone receptor status (ER / PR), Letrozole (and other aromatase inhibitors), Tamoxifen.
Shares Lobular carcinoma in situ (LCIS), Letrozole (and other aromatase inhibitors), Tamoxifen, CDK4/6 inhibitors.
Shares Menopause brought on by cancer treatment, and the options for it, Bone loss caused by cancer treatment, and what rebuilds it, Tamoxifen, HR-positive / HER2-negative breast cancer.
Shares Lobular carcinoma in situ (LCIS), Tamoxifen, Endocrine therapy (SERMs, AIs, SERDs).