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Glossary
Aquagenic pruritus

Aquagenic pruritus

Intense itching, prickling or burning of the skin within minutes of contact with water, typically after a shower. It affects a large minority of people with polycythaemia vera and can be the most disabling symptom.

Overview Connected4

Overview

Aquagenic pruritus has no rash and is triggered by water of any temperature. It is thought to involve mast cells and abnormal skin nerve signalling driven by the JAK2 clone. Antihistamines help some; JAK inhibition with ruxolitinib and interferon are the most effective treatments, and phototherapy and SSRIs are used when those are not suitable.

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Ruxolitinib

Showing the molecule this term concerns: Ruxolitinib.

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Similar pages

Term
JAK2 V617F
Shares Ropeginterferon alfa-2b, Polycythaemia vera (PV), Ruxolitinib, Myeloproliferative neoplasms (PV, ET, myelofibrosis) and the tags polycythaemia-vera, mpn.
Trial
RESPONSE-2
Shares Polycythaemia vera (PV), Ruxolitinib and the tags polycythaemia-vera, mpn.
Term
Post-PV myelofibrosis (spent phase)
Shares Polycythaemia vera (PV), Ruxolitinib, Myeloproliferative neoplasms (PV, ET, myelofibrosis) and the tags polycythaemia-vera, mpn.
Trial
RESPONSE
Shares Polycythaemia vera (PV), Ruxolitinib, Myeloproliferative neoplasms (PV, ET, myelofibrosis) and the tags polycythaemia-vera, mpn.
Trial
Low-PV
Shares Ropeginterferon alfa-2b, Polycythaemia vera (PV) and the tags polycythaemia-vera, mpn.
Term
Erythromelalgia
Shares Polycythaemia vera (PV), Myeloproliferative neoplasms (PV, ET, myelofibrosis) and the tags polycythaemia-vera, mpn.
Trial
PROUD-PV and CONTINUATION-PV
Shares Ropeginterferon alfa-2b, Polycythaemia vera (PV), Myeloproliferative neoplasms (PV, ET, myelofibrosis) and the tags polycythaemia-vera, mpn.
Idea
Clearing the JAK2 clone in polycythaemia vera: interferon plus mutant-selective inhibitors as a route to treatment-free remission
Shares Ropeginterferon alfa-2b, Polycythaemia vera (PV), Ruxolitinib, Myeloproliferative neoplasms (PV, ET, myelofibrosis) and the tags polycythaemia-vera, mpn.

cancers

Myeloproliferative neoplasms (PV, ET, myelofibrosis)Polycythaemia vera (PV)

drugs

ApprovedLong-acting mono-pegylated interferon alfa

Ropeginterferon alfa-2b · Besremi

ApprovedSmall-molecule JAK1/JAK2 inhibitor

Ruxolitinib · Jakafi / Jakavi

ProvenanceLast edited 2026-09-16 · Jude Gomila · Polycythaemia vera · diff · file

Wikipedia

Aquagenic pruritus

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polycythaemia-vera mpn

Data

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Cancers

Polycythaemia vera (PV)
Myeloproliferative neoplasms (PV, ET, myelofibrosis)

Products

Ruxolitinib
Ropeginterferon alfa-2b

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MCP server: npx -y onco-mcp, tools search, get_entity, list_kind, ask, context, compare. This record is get_entity or context with id aquagenic-pruritus.

WebMCP tools registered on this page: onco_search, onco_get_entity.