Loading
Scan after two cycles of chemotherapy; if the tumour has gone dark, give less treatment, and if not, give more. Hodgkin lymphoma pioneered this.
Interim FDG-PET after cycle 2 (PET2) scored on the Deauville scale steers escalation or de-escalation: RATHL (omit bleomycin if PET2-negative, no loss of efficacy), HD18 (shorten escalated BEACOPP), HD16/HD17 and RAPID (omit radiotherapy in early stage if PET-negative, at a small PFS cost), and HD21/S1826 (PET-guided consolidation). Being extended to DLBCL and to ctDNA-adapted designs.
FDG-PET measures metabolic response early; Deauville ≥4 at PET2 predicts failure, allowing therapy to be tailored before completion.
Query for this technology: (TITLE:"PET-adapted response-adapted therapy" OR ABSTRACT:"PET-adapted response-adapted therapy") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PET-adapted (response-adapted) therapy, not a curated reading list.
Shares Escalated chemotherapy or ABVD in advanced Hodgkin lymphoma: more cures, more late harm, and what the interim scan changed, Early-stage classical Hodgkin lymphoma (stage I to II), Advanced-stage classical Hodgkin lymphoma (stage III to IV), Primary mediastinal (thymic) large B-cell lymphoma.
Shares Escalated chemotherapy or ABVD in advanced Hodgkin lymphoma: more cures, more late harm, and what the interim scan changed, RATHL, GHSG HD21, Early-stage classical Hodgkin lymphoma (stage I to II).
Shares IELSG37, Radiotherapy in lymphoma: involved-site fields, 24 Gy, 4 Gy and total skin electron therapy, FDG PET, Early-stage classical Hodgkin lymphoma (stage I to II).
Shares Deauville five-point scale, Radiotherapy in lymphoma: involved-site fields, 24 Gy, 4 Gy and total skin electron therapy, FDG PET, Primary mediastinal (thymic) large B-cell lymphoma.
Shares Caution: bleomycin lung toxicity, especially with brentuximab or G-CSF, Escalated chemotherapy or ABVD in advanced Hodgkin lymphoma: more cures, more late harm, and what the interim scan changed, GHSG HD21, Advanced-stage classical Hodgkin lymphoma (stage III to IV).
Shares RATHL, GHSG HD21, Early-stage classical Hodgkin lymphoma (stage I to II), Advanced-stage classical Hodgkin lymphoma (stage III to IV).
Shares Chemotherapy-free Hodgkin lymphoma: brentuximab + PD-1 in early stage, Early-stage classical Hodgkin lymphoma (stage I to II), Advanced-stage classical Hodgkin lymphoma (stage III to IV), Primary mediastinal (thymic) large B-cell lymphoma.
Shares GHSG HD21, Early-stage classical Hodgkin lymphoma (stage I to II), Advanced-stage classical Hodgkin lymphoma (stage III to IV), Primary mediastinal (thymic) large B-cell lymphoma.