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For young women with the earliest, low-grade endometrial cancers, progestin pills or a hormonal IUD can clear the cancer and allow pregnancy before a later hysterectomy.
Candidates: grade 1 endometrioid carcinoma confined to the endometrium on MRI, PR-positive, no myometrial invasion. Complete response ~70-80% at 12 months with oral megestrol/medroxyprogesterone or a levonorgestrel IUD (often combined with metformin or hysteroscopic resection); recurrence ~30%; live-birth rates ~30-40% with assisted reproduction. Hysterectomy after childbearing is recommended.
Progestin-induced differentiation and apoptosis of hormone-responsive endometrial cancer cells under close endometrial sampling surveillance.
Query for this technology: (TITLE:"Fertility-sparing hormonal treatment of early endometrial cancer" OR ABSTRACT:"Fertility-sparing hormonal treatment of early endometrial cancer") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Fertility-sparing hormonal treatment of early endometrial cancer, not a curated reading list.
Shares Progestins (megestrol acetate, medroxyprogesterone, levonorgestrel IUD), Endometrial cancer.
Shares Progestins (megestrol acetate, medroxyprogesterone, levonorgestrel IUD), Endometrial cancer.
Shares Progestins (megestrol acetate, medroxyprogesterone, levonorgestrel IUD), Endometrial cancer.
Shares Progestins (megestrol acetate, medroxyprogesterone, levonorgestrel IUD), Endometrial cancer.
Shares Progestins (megestrol acetate, medroxyprogesterone, levonorgestrel IUD), Endometrial cancer with no specific molecular profile, Endometrial cancer.
Shares Endometrial cancer with no specific molecular profile, Endometrial cancer.
Shares Endocrine therapy (SERMs, AIs, SERDs), Endometrial cancer.
Shares Endometrial cancer with no specific molecular profile, Endometrial cancer.