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Fishing whole cancer cells out of a blood sample to count them or study them; the count is prognostic in breast, prostate and colorectal cancer.
Circulating tumour cells (CTCs) are rare cells shed by tumours into blood, roughly one per billion blood cells. The CellSearch system, cleared by the FDA in 2004, enriches them by EpCAM antibody capture and counts them; higher counts predict shorter survival in metastatic breast, prostate and colorectal cancer. Microfluidic and size-based methods capture EpCAM-negative cells, and single CTC sequencing and culture are used in research; CTC counts have not yet changed treatment in randomised trials.
Immunomagnetic or microfluidic enrichment of cells by surface antigen, size or deformability, followed by staining and enumeration or molecular analysis.
Query for this technology: (TITLE:"Circulating tumour cell capture" OR ABSTRACT:"Circulating tumour cell capture") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Circulating tumour cell capture, not a curated reading list.