Loading
ZXDB (Zinc finger X-linked protein ZXDB) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Invasive Breast Carcinoma.
In plain words · ZXDB (Zinc finger X-linked protein ZXDB) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
ZXDB (Zinc finger X-linked protein ZXDB) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. Location: Nucleus (UniProt).
No product in this corpus aims at ZXDB yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1993. Earliest sequence paper UniProt cites for the protein: Greig G.M. et al, Hum. Mol. Genet, 1993, "Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies". Source.
Sources: HGNC HGNC:13199 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P98169 (protein name, function text, keywords and locations (REST API)); IntOGen ZXDB (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. Location: Nucleus (UniProt). Locus Xp11.21 (HGNC).
Query for this target: (TITLE:"ZXDB" OR ABSTRACT:"ZXDB" OR TITLE:"zinc finger X-linked duplicated B" OR ABSTRACT:"zinc finger X-linked duplicated B" OR TITLE:"Zinc finger X-linked protein ZXDB" OR ABSTRACT:"Zinc finger X-linked protein ZXDB" OR TITLE:"ZNF905" OR ABSTRACT:"ZNF905") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZXDB, not a curated reading list.