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ZNF395 (Zinc finger protein 395) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
Plays a role in papillomavirus genes transcription.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Non-Small Cell Lung Cancer.
In plain words · ZNF395 (Zinc finger protein 395) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
ZNF395 (Zinc finger protein 395) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.
Plays a role in papillomavirus genes transcription. Location: Cytoplasm; Nucleus (UniProt).
No product in this corpus aims at ZNF395 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2002. Earliest sequence paper UniProt cites for the protein: Boeckle et al, Virology, 2002, "A new cellular factor recognizes E2 binding sites of papillomaviruses which mediate transcriptional repression by E2". Source.
Sources: HGNC HGNC:18737 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H8N7 (protein name, function text, keywords and locations (REST API)); IntOGen ZNF395 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Plays a role in papillomavirus genes transcription. Location: Cytoplasm; Nucleus (UniProt). Locus 8p21.1 (HGNC).
Query for this target: (TITLE:"ZNF395" OR ABSTRACT:"ZNF395" OR TITLE:"zinc finger protein 395" OR ABSTRACT:"zinc finger protein 395" OR TITLE:"Zinc finger protein 395" OR ABSTRACT:"Zinc finger protein 395" OR TITLE:"PRF-1" OR ABSTRACT:"PRF-1" OR TITLE:"HDBP2" OR ABSTRACT:"HDBP2" OR TITLE:"DKFZp434K1210" OR ABSTRACT:"DKFZp434K1210") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF395, not a curated reading list.