Loading
ZCRB1 (Zinc finger CCHC-type and RNA-binding motif-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
UniProt has no function text for Q8TBF4; HGNC names it "zinc finger CCHC-type and RNA binding motif containing 1".
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.
In plain words · ZCRB1 (Zinc finger CCHC-type and RNA-binding motif-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
ZCRB1 (Zinc finger CCHC-type and RNA-binding motif-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
UniProt has no function text for Q8TBF4; HGNC names it "zinc finger CCHC-type and RNA binding motif containing 1". Location: Nucleus, nucleoplasm (UniProt).
No product in this corpus aims at ZCRB1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:29620 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8TBF4 (protein name, function text, keywords and locations (REST API)); IntOGen ZCRB1 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
UniProt has no function text for Q8TBF4; HGNC names it "zinc finger CCHC-type and RNA binding motif containing 1". Location: Nucleus, nucleoplasm (UniProt). Locus 12q12 (HGNC).
Query for this target: (TITLE:"ZCRB1" OR ABSTRACT:"ZCRB1" OR TITLE:"zinc finger CCHC-type and RNA binding motif containing 1" OR ABSTRACT:"zinc finger CCHC-type and RNA binding motif containing 1" OR TITLE:"Zinc finger CCHC-type and RNA-binding motif-containing protein 1" OR ABSTRACT:"Zinc finger CCHC-type and RNA-binding motif-containing protein 1" OR TITLE:"MADP-1" OR ABSTRACT:"MADP-1" OR TITLE:"MADP1" OR ABSTRACT:"MADP1" OR TITLE:"RBM36" OR ABSTRACT:"RBM36") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZCRB1, not a curated reading list.